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An information technology infrastructure supports the biotech knowledge management process by providing computation, communications, control, and data storage. These provisions can be appreciated in the context of the knowledge management process associated with the pharmacogenomic lab oratory depicted in Figure 5.1. The gure shows data-collection, databases, and analysis tools, all networked to support the knowledge management process. The data serve as the basis of online publication in applications from drug discovery to genetic engineering. The amount of data owing through the lab is astronomical. There are numerous data sources, including the patients, clinical studies, ge nomic studies, and public and private online databases. Data of various types are acquired from a variety of sources, incorporated into databases, manipulated, transformed, and archived for future use. In addition, there are a variety of applications that can be brought to bear on genomic and

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(12.3.28)

In (12.3.27), SIP denotes Sommerfeld integration path (Fig. 12.3.2). We illustrate for z < z'. We have

(12.3.30)

for l = 0 for l = 1,2, ...

It is normally considered inappropriate programming practice to use hard-coded strings in your code, as in this code example It is better to de ne the string names of your stored procedures as constants in the associated business object, or as resource strings in the business object Class Library project properties, as described in 4

2 -1

(12.3.31)

< p'

pharmacogenomic laboratory environment, showing clinical and laboratory datacollection, databases, and analysis tools, all networked to support the knowledge management process.

04>' =

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For the Purchase Tracker sample application: You already have a reference in the business object Class Library project (PTBO) to the DAC Class Library component (PTDAC), as detailed in 3 In the business object Class Library project (PTBO), add a constant to the associated class or resource string to the project properties for each stored procedure name as follows:

1/(1 ' "

(1 + e-2ikz(z'-~)) eikz(z'-~)

-TE d I 04>' = RgH n (kpl,kzl,p,z+2)rLn(kpl,kzl,p)e-m It (12.3.32)

> p'

Resource String/Constant Name SP_CustomerRetrieveByID SP_CustomerRetrieveList SP_CustomerSave SP_ProductRetrieveByID SP_ProductRetrieveList SP_ProductSave SP_PurchaseRetrieveByCustomerID Stored Procedure Name CustomerRetrieveByID_sp CustomerRetrieveList_sp CustomerSave_sp ProductRetrieveByID_sp ProductRetrieveList_sp ProductSave_sp PurchaseRetrieveByCustomerID_sp

G(r, r ' ) . It = -

4: L (_~t+l 11 (1 + e-2ikz(Z'-~)) eikz(z'-~)

(1 + e-2ikz(z'-~)) eikz(z'-~)

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clinical data, and the biomedical literature, which help researchers gener ate more data Computational tasks enabled by the IT infrastructure range from searching for nucleotide sequences and visualizing protein-folding pat terns to simulating complex protein-protein interactions These tasks are undertaken for applications ranging from drug discovery to biomaterials research and development Furthermore, embedded computer controllers operate sequencing machines, fermentation tanks, bioreactors, and the robotic arms that perform repetitive tasks in the lab Celera Genomics was able to sequence the human genome in part because of the computerdirected robots that automated the tedious gene-sequencing process that generated a quarter trillion genomic sequences every hour As a communications medium, modern computer networks enable re searchers to collaborate directly with each other and to publish their re search online and later in print.

04>' =

Open the ProductList class in the Code Editor In the Create method, remove the hard-coded data values, and insert a call to the DAC ExecuteDataTable method Pass in the appropriate resource string or constant for the stored procedure name:

It (12.3.33)

< p', we have, similarly,

G(r, r ' ) . It = -

4: L (_~t+l fz (1 + e2ikz(Z'+~)) e-ikz(z'+~)

(1 + e2ikz(Z'+~)) e-ikz(z'+~)

dt = DACExecuteDataTable( _ MyResourcesSP_ProductRetrieveList)

(12.3.34)

> Zl, P > p'

Most biotech researchers consult the numerous public databases on the Web or one of the value-added com mercial databases for the latest information on biotech research Not only are articles in print typically considered historical documents, but if a printed journal article describing the research isn t referenced by one of the online electronic reference databases (such as the US National Li brary of Medicine s PubMed), then the chances of the printed article ever being read are minimal Computation, communications, and control all revolve around data maintained in computer databases, including the hundreds of public biotech databases accessible through the Internet International genomic sequence databases include GENBANK, which is supported by the Na tional Center for Biological Information (NCBI), the DNA DataBank of Japan (DDBJ), and the European Molecular Biology Laboratory (EMBL) PubMed, which is maintained by the US.

1] G(r, r ' ) . = = - 4d ' " (_l)n+1 11 ( 1 + e2 k z ('+d)) It L k2 ~ z "2

'k z (z '+d) 2

Open the CustomerList class in the Code Editor In the Create method, remove the hard-coded data values, and insert a call to the DAC ExecuteDataTable method Pass in the appropriate resource string or constant for the stored procedure name:

zT) '""'

- TE _

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